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Conference Schedule

April 8-10, 2027

* This is a tentative schedule that may be subject to change. All times are Pacific Daylight Time (PDT).

Thursday, April 8,

7:45am - 8:00am
Opening Remarks
8:00am –
9:00am
Lyme Disease
Pediatrics

Beyond the Bug: Supporting Pediatric Terrain in Lyme and Vector-Borne Diseases

Objectives
  • To recognize pediatric clinical patterns of Lyme and vector-borne diseases
  • To understand pediatric-specific pathophysiology
  • To apply a terrain-based framework
  • To evaluate integrative treatment strategies
  • To implement safe pediatric dosing principles
  • To review congenital vector-borne transmission pathways and effects during pregnancy
9:00am –
10:00am
Autoimmunity
Lyme Disease

Cerebral Folate Deficiency in Vector-Borne Disease: Evidence for Folate Receptor Autoimmunity as a Contributor to Neuropsychiatric Symptoms

Objectives
  • To describe the pathophysiology of cerebral folate deficiency (CFD) and the role of folate receptor alpha autoantibodies (FRAA) in impairing central nervous system folate transport
  • To summarize the evidence linking cerebral folate deficiency to psychiatric and neuroimmune conditions
  • To summarize new data on FRAA prevalence in vector-borne disease
  • To assess the clinical utility of FRAA testing in patients with vector-borne disease
  • To apply targeted treatment strategies including nutritional recommendations and folinic acid supplementation
10:00am - 10:30am
Break
10:30am –
11:30am
Ehlers-Danlos Syndrome
Pediatrics

Lions and Tigers and Zebras, Oh My!: Recognition, Evaluation, and Treatment of Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders (EDS/HSD) in Neurodiversity

Objectives
  • To become aware of the current/growing prevalence and co-occurrence of Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders (EDS/HSD), and the overlapping symptomology that impacts quality of life To understand the overlap of EDS/HSD with neurodiversity in the pediatric population as well as adults
  • To gain tools for diagnosing EDS/HSD in the neurodiverse population with updated diagnostic criteria
  • To gain treatment options to apply in clinical practice, including appropriate referral options, conservative therapies, pharmacologic and supplement treatments for symptoms
  • To review integrative medicine applications to consider for improving quality of life for hypermobile patients
11:30am –
12:30pm
Microbiome

Personalizing Microbiome Recovery in the Chronically Ill Patient: Advanced Testing, the Resilience Paradox, and What To Do During Long-term Antimicrobial Therapy

Presented by:
Objectives
  • To review the patterns that emerge from serial shotgun metagenomic testing in chronically ill children and adults
  • To understand how early-life microbiome disruption shapes the adult ecosystem, and how microbiome resilience is a double-edged sword
  • To learn how shotgun metagenomics can personalize a microbiome recovery plan for your complex, chronically ill patients beyond qPCR and 16S sequencing, and also understand the limits in identifying fungal colonization and parasite detection in any microbiome test
  • To discover what “leaky gut” is actually an indicator of, and the evidence behind which intestinal permeability tests have validity on behind them
  • To review the emerging evidence for human milk oligosaccharides beyond infancy, including adult clinical data
  • To apply a practical framework for restoring microbiome resilience even while our complex patients are on longterm antimicrobial therapy
12:30pm - 1:45pm
Lunch
1:45pm –
2:45pm
SIBO
Microbiome

SIBO Evolved: New Discoveries and Practical Solutions for Tough Cases

Objectives
  • To recognize tough SIBO cases in a clinical setting and tailor treatment options to improve patients' overall quality of life
  • To understand what causes tough SIBO cases
  • To learn the updated SIBO type nomenclature and associated microbes
  • To evaluate new clinical testing options for SIBO
  • To apply new treatment approaches for SIBO in the clinical setting
2:45pm –
3:45pm
Cancer

The Metabolic Approach to Life: Understanding the Terrain of Cancer and Chronic Disease

Objectives
  • To review why chronic disease and cancers are increasing and to have a better understanding of the current environmental pressures
  • To understand the terrain of our body and how to view it through different lenses
  • To discover different ways to assess the terrain: choosing different routes of testing
  • To understand treatment options, interventions are not based on the diagnosis; they are based on current data derived from testing
  • To understand the only cure is prevention
3:45pm - 4:15pm
Break
4:15pm –
5:15pm
Practice Management

Is Every Patient the Right Fit for You: How to Optimize Your Practice and Prevent Burnout

Presented by:
Objectives
  • To understand the types of patient personalities that might prove difficult over time
  • To review "red flag" behaviors that could create difficulties in communication and compliance
  • To understand how to appreciate boundaries, or lack thereof, set by patients
  • To understand how our written or implied contracts and expectations with patients could get us into trouble
  • To appreciate our own best efforts in creating meaningful communication and honoring that
5:15pm - 6:00pm
Q&A

Friday, April 9,

7:45am - 8:00am
Opening Remarks
8:00am –
9:00am
Alzheimer’s
Brain Health

Chess With the Devil: Reversing Cognitive Decline

Objectives
  • To learn the systems biology of Alzheimer’s disease
  • To learn the various contributors to cognitive decline and risk for decline
  • To learn the basics of treatment for patients with cognitive decline
  • To learn about blood-based biomarkers of Alzheimer’s disease
  • To learn about typical and atypical presentations of Alzheimer’s disease, such as PCA and CBS
  • To learn the results of recent clinical trials of precision medicine for cognitive decline
9:00am –
10:00am
Long COVID
Autoimmunity
Brain Health

From Concept to Bench: the Journey Behind the Development of the Long COVID and Brain Health Panel

Objectives
  • To learn how years of research help in experimental design that may end in a major breakthrough in the field of medicine
  • To see what research findings formed the base for calling SARS-CoV-2 the “Autoimmune Virus”
  • To review the factors involved in Long COVID and why about 10% of the population developed this disorder that shares similarity with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
  • To discover how leaky blood-brain barriers and hyperactive microglial cells help in the spreading of Long COVID into the brain
  • To understand how all this information, research, time and effort resulted in a panel of lab tests for confirming the effects of Long COVID on brain health
10:00am - 10:30am
Break
10:30am –
11:30am
Mold Illness
Long COVID
Brain Health

Sequencing Conditions and Treatments In Complex Brain and Body Fatigue Cases: Determining When and If to Treat Mold, Metals, Toxins, and Long COVID

Objectives
  • To determine the most important factors to prioritize in treatment
  • To sequence treatment interventions strategically for optimal outcomes
  • To identify the most important factors to address in Long COVID and when to treat them
  • To differentiate the role of spike protein from other contributors to Long COVID
  • To determine treatment priorities and sequencing using patient history and muscle testing
  • To sequence treatment for coinfections, mold mycotoxins, heavy metals, and Long COVID
  • To recognize when and how to directly support mitochondrial function
  • To treat brain inflammation to improve vagus nerve function
11:30am –
12:30pm
Functional Psychiatry
Brain Health

Functional Psychiatry: Rethinking Depression and Anxiety Through the Lens of Root Cause Medicine

Objectives
  • To define functional psychiatry and describe its foundational principles as applied across clinical specialties in the treatment of depression and anxiety
  • To explain the multifactorial nature of mental health disorders, including the genetic, environmental, and lifestyle factors that contribute to depression and anxiety
  • To identify the key domains of a functional psychiatry evaluation relevant to assessing depression and anxiety
  • To differentiate the functional psychiatry diagnostic approach from traditional psychiatric diagnostic criteria in identifying the root causes of mental health conditions
  • To recognize common root causes of depression and anxiety uncovered through a functional psychiatry framework
  • To apply multimodal interventions to treat depression and anxiety in clinical practice
12:30pm - 1:45pm
Lunch
1:45pm –
2:45pm
Cell Danger Response
Mold Illness
Mitochondria

Mold Illness and the Cell Danger Response: The New Science

Objectives
  • To examine the biology of the cell danger response
  • To apply mitochondrial testing in a mold illness population
  • To synthesize basic science and clinical acumen to improve outcomes in mold illness
  • To compare and contrast the CDR to CIRS (Chronic Inflammatory Response Syndrome)
  • To apply a longevity and resiliency model to mold illness to enhance recovery and build robustness
  • To integrate mind body strategies into the clinical management of the CDR protocol
2:45pm –
3:45pm
Mast Cell Activation Syndrome
Peptides

MCAS in 2027: Advances in Treatment and the Emerging Role of GLP-1s

Objectives
  • To describe our evolving understanding of MCAS and its underappreciated role in the increasing incidence of chronic disease
  • To identify the major triggers and drivers of MCAS, including infections, mold and environmental exposures, connective tissue disorders, and mechanical or hormonal contributors
  • To evaluate the emerging evidence for GLP-1 receptor agonists in mast cell activation disease
  • To discover how GLP-1 therapy fits into a broader treatment strategy combining mast cell stabilization, root-cause investigation, and targeted treatment of underlying contributors
3:45pm - 4:15pm
Break
4:15pm –
5:15pm
Mast Cell Activation Syndrome

Navigating the Multiverse of MCAS: What Complex Patients Have Taught Me About Healing

Objectives
  • To understand why MCAS rarely follows predictable clinical pathways
  • To learn how to identify and prioritize the many factors that perpetuate MCAS
  • To discover and optimize treatment sequencing
  • To explore a broader therapeutic toolbox for MCAS
  • To learn how to recognize common clinical missteps that can derail treatment
  • To recognize the relationship between physiological reactivity, the ANS, and patient’s internal sense of safety
  • To discover how listening to the patient’s lived experience, including applying different paradigms for assessing symptoms, can reveal important clinical information and open up new avenues for healing
5:15pm - 6:00pm
Q&A
6:00pm - 8:00pm
Reception

Saturday, April 10,

7:45am - 8:00am
Opening Remarks
8:00am –
9:00am
Cell Membrane Medicine

Caveolae, Lipid Droplets: Their Relationship to Cellular Toxicity and Neurological Function

Objectives
  • To describe the molecular composition and function of caveolae and lipid droplets
  • To explain the mechanisms underlying cellular toxicity and its impact on health
  • To review current research on the roles of caveolae and lipid droplets in cellular biology
  • To identify how caveolae and lipid droplets support cellular detoxification, neuronal function, and overall cellular health
  • To apply biological substrate-based strategies to enhance cellular function and resilience
9:00am –
10:00am
Cell Membrane Medicine
Cell Danger Response

Why Complex Chronic Illness Patients Get Stuck: Membrane Dysfunction, Treatment Intolerance, and a Practical Path to Recovery

Presented by:
Objectives
  • To understand how membrane dysfunction and oxidative stress reduce treatment tolerance
  • To review the Cell Danger Response and how persistent defensive physiology can keep patients stuck
  • To learn the Five Stages of Healing and a practical approach to membrane repair
  • To identify a patient’s current stage using readiness markers and physiologic reserve
  • To apply stage-based sequencing to clinical cases and decide what to treat first, defer, or reassess
10:00am - 10:30am
Break
10:30am –
11:30am
Cell Membrane Medicine
Ketamine
Cell Danger Response

The Neurometabolic Approach to Cellular Restoration

Objectives
  • To identify and interpret biomedical strategies to address cellular ‘static’ and endoplasmic and mitochondrial derangement driven by toxic insult resulting in altered gene expression, the formation of aberrant lipids and proteins which ultimately alter lipid metabolism in chronic and neurological disorders through appropriate testing and targeted lipid treatment protocols
  • To discover the use of pinpoint therapy using microdosing of ketamine once there is clearance of cellular debris and stabilization of the lipid membranes with oral and intravenous bioactive lipids and phospholipids
  • To discuss the alteration of the clinical course of acute and chronic states of disease by detailed examination of red cell fatty acids and phospholipids (unsaturated, saturated, oxidized, lyso) in university-based laboratories to obtain accurate data to assess the degree of epigenetic insult, endoplasmic and mitochondrial stress resulting in an accumulation of aberrant fatty acids and proteins forming debris which destabilizes organelle and cell membrane architecture and metabolism
  • To evaluate and fully appreciate epigenetic factors, DNA adducts and adverse effects upon gene expression and phospholipid membrane derangement, unfolded protein response also described as the Cell Danger Response, as it relates to neurological degradation, chronic disease and pain syndromes
  • To discuss the role of stabilization of cardiolipin, myelin, cells/ organelles, and membranes as new therapeutic targets in neurometabolic and chronic disease
11:30am –
12:30pm
Peptides
Mitochondria

Peptide Therapies for Cellular Reprogramming, Mitochondrial Health, and Healthspan Optimization

Objectives
  • To understand how peptides can improve chronic illness
  • To learn which specific peptides can improve patient recovery
  • To learn about peptide related Mitochondria repair
  • To learn protocols for improving longterm chronic illness
12:30pm - 1:45pm
Lunch
1:45pm –
2:45pm
Hyperbaric Oxygen Therapy

Hyperbaric Oxygen: Effect on Stem Cell Mobilization, Inflammation, Cell Signaling, and Cellular Regeneration

Objectives
  • To gain a basic understanding of hyperbaric oxygen therapy
  • To review the mechanism of action of HBOT
  • To understand where HBOT fits inside an integrative medicine clinic/program
  • To review current hyperbaric research pertaining to the above
2:45pm –
3:45pm
Women’s Hormones

Optimizing Female Healthspan with Physiologic Hormones and Rhythms

Presented by:
Objectives
  • To discover the rarely discussed importance of optimal levels of estradiol and progesterone from menarche, throughout the reproductive stage of life, and during the menopause years
  • To review the menstrual cycle and recognize its importance for global female health, in addition to its importance for reproductive success
  • To discover the bidirectional role of estradiol and mitochondria and the interconnection of the essential roles they play in establishing and maintaining optimal female health throughout all of the decades of adult life
  • To understand the impacts of hormonal imbalances during the reproductive years and of loss of these vital hormones with the onset of menopause on health optimization and healthspan
  • To create a plan for female health optimization and healthspan utilizing human bioidentical hormones and lifestyle medicine, including evidence-based supplements and nutraceuticals
3:45pm - 4:15pm
Break
4:15pm –
5:15pm
Biological Dentistry

Open Wide: Understanding the Oral-Systemic Health Connection

Objectives
  • To understand the role of the oral microbiome in local and systemic inflammation
  • To review the biological mechanisms of gum, tooth, and jaw infections
  • To discover the latest diagnostic technologies that help identify oral disease earlier
  • To learn about minimally invasive therapies that target disease at the source and promote regeneration
  • To understand how persistent chronic diseases, such as Lyme disease and associated co-infections, can harbor in sites of oral infection
5:15pm - 6:00pm
Q&A